Tag Archives: Nitrict Oxide Synthase

L-arginine comes primarily from dietary intake, and is the only starting point for the Nitric Oxide Synthase pathway. When the electrical signal of sexual arousal activates the NOS pathway, L-arginine becomes converted into nitric oxide. Nitric oxide acts as a vasodilator and promotes yet another more powerful element, cyclic-GMP, a very potent vasodilator.

While the Nobel Prize in Medicine was not awarded for the knowledge that to have an orgasm it is essential to become maximally sexually aroused with a clitoral erection, the discovery of the science underlying genital erection did. The physiology that enables a woman to establish a clitoral erection (and a man a penile erection) is the Nitric Oxide Synthase Pathway. The discovery of this pathway was the basis of the 1998 Nobel Prize in Medicine. Now we know that the NOS pathway explains how a signal originating in the brain and traveling via the nerves (esp. the clitoral nerve) causes the release of nitric oxide, the key event that results in clitoral engorgement and clitoral erection.

Vasodilators is like throwing gasoline onto a smoldering fire, causing a large and rapid reaction. This NOS mechanism creates maximum sexual arousal and clitoral erection by inducing the activity of nitric oxide with L-arginine.